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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
26.97
Human Site:
T377
Identified Species:
39.56
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
T377
F
P
R
D
L
N
L
T
V
L
V
E
Q
Q
T
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
T377
F
P
R
D
L
N
L
T
V
L
V
E
Q
Q
T
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
T377
F
P
R
D
L
N
L
T
V
L
V
E
Q
Q
T
Dog
Lupus familis
XP_546656
989
110956
T377
F
P
K
D
L
D
L
T
V
L
V
E
Q
Q
T
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
V377
F
P
K
D
L
N
L
V
A
L
V
E
Q
Q
T
Rat
Rattus norvegicus
XP_002742497
1001
111922
X377
K
L
X
X
X
X
X
X
X
X
X
X
X
X
X
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
V420
F
P
K
D
L
N
L
V
A
L
V
Q
Q
Q
T
Chicken
Gallus gallus
NP_001025807
1020
114626
S379
F
P
K
E
L
N
L
S
A
L
V
Q
H
Q
T
Frog
Xenopus laevis
NP_001085699
1022
114003
T382
F
P
K
D
L
N
L
T
S
L
V
E
Q
Q
T
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
T375
F
P
Q
N
L
N
L
T
R
L
V
E
Q
Q
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
A371
F
S
K
E
F
A
L
A
P
L
V
E
M
Q
T
Honey Bee
Apis mellifera
XP_394050
958
109977
I345
F
P
K
E
L
N
L
I
S
L
V
N
Q
Q
I
Nematode Worm
Caenorhab. elegans
O61660
759
85420
Q190
G
S
A
F
T
R
L
Q
T
L
H
L
R
N
R
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
A110
K
R
T
L
E
R
E
A
R
A
A
D
V
L
V
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
Y335
Y
Q
A
G
F
I
S
Y
P
R
T
E
T
D
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
R357
F
S
S
R
T
D
L
R
A
M
V
E
E
Q
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
100
86.6
N.A.
80
0
N.A.
73.3
60
86.6
80
N.A.
46.6
60
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
0
N.A.
86.6
86.6
93.3
93.3
N.A.
60
73.3
20
6.6
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
13
0
0
7
0
13
25
7
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
44
0
13
0
0
0
0
0
7
0
7
0
% D
% Glu:
0
0
0
19
7
0
7
0
0
0
0
63
7
0
0
% E
% Phe:
75
0
0
7
13
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% H
% Ile:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
7
% I
% Lys:
13
0
44
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
7
0
7
63
0
82
0
0
75
0
7
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% M
% Asn:
0
0
0
7
0
57
0
0
0
0
0
7
0
7
0
% N
% Pro:
0
63
0
0
0
0
0
0
13
0
0
0
0
0
0
% P
% Gln:
0
7
7
0
0
0
0
7
0
0
0
13
57
75
0
% Q
% Arg:
0
7
19
7
0
13
0
7
13
7
0
0
7
0
7
% R
% Ser:
0
19
7
0
0
0
7
7
13
0
0
0
0
0
7
% S
% Thr:
0
0
7
0
13
0
0
38
7
0
7
0
7
0
69
% T
% Val:
0
0
0
0
0
0
0
13
25
0
75
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _